Fluorescence Immunoassay C-Reactive Protein – Product code: SC-1361-20
Rapid test for the diagnosis of inflammatory state and ACS by measuring CRP/hs-CRP on whole blood, serum or plasma with the use of the Immunofluorescence Analyzer. The CRP Cassette Test (Whole Blood/Serum/Plasma) is based on immunofluorescence to quantitatively determine C-Reactive Protein (CRP) in serum, plasma or whole blood to aid in the evaluation of infections, tissue damage and inflammatory disorders in conjunction with high sensitivity CRP measurement (hs-CRP) for the evaluation of acute coronary syndromes (ACS). C-reactive protein is an acute phase reagent precipitated with Polysaccharide C Pneumococcus and is a component of the non-specific immune response. CRP is widely distributed in our body and is an acute phase protein produced by the liver in response to a microbial infection from tissue damage, measures general levels of inflammation in the body, and hs-CRP can be used to detect higher concentrations. low CRP in serum or plasma. Some studies have shown a correlation between hs-CRP levels and Atherosclerosis and Acute Myocardial Infarction. HS-CRP is an inflammatory marker for ACS patients and a valuable aid in primary prevention and in assessing the risk of cardiovascular disease. Its combination with the ratio of total cholesterol to HDL-C is more accurate than other risk factors in predicting cardiovascular disorders. The American Heart Association and the US Centers for Disease Control and Prevention have indicated hs-CRP as a predictor of cardiovascular disorder (CVD) when defining risk groups: less than 1.0 mg/L indicates low risk , 1.0 to 3.0 mg/L indicates moderate risk, above 3.0 mg/L (but below 10 mg/L) strongly suggests a high risk of CVD. Additionally, higher CRP levels can be found in pregnancy, moderate inflammation, viral infection (10 ~ 40mg/L), active inflammation, bacterial infection (40 ~ 200mg/L), severe bacterial infection and burns (200 mg/L). The CRP Cassette Test is based on immunofluorescence. The sample moves across the strip from the sample pad to the absorbent pad. If the sample contains CRP, it attaches to the fluorescent beads conjugated to anti-CRP antibodies. Then the compound is captured by the capture antibodies placed on the nitrocellulose membrane (Test line). The concentration of CRP in the sample is directly proportional to the intensity of the fluorescent signal captured on the T-line. Depending on the intensity of the fluorescence on the test and the standard curve, the concentration of CRP in the sample is calculated by the SCREEN® Analyzer to show the concentration of CRP in the sample.