SCREEN IFA TEST MICROALBUMINURIA

Fluorescence Immunoassay Microalbumin

Product code: SC-1330-20

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Fluorescence Immunoassay Microalbumin – Product code: SC-1330-20

Rapid test for the measurement of Microalbumin in urine with the use of the Immunofluorescence Analyzer. For professional in vitro diagnostic use only. The Microalbumin Cassette Test (Urine) is based on immunofluorescence to measure the Microalbumin in urine. The constant elimination of small amounts of albumin in the urine can be the first symptom of kidney damage. In the healthy kidney, albumin is usually glomerularly filtered and tubularly reabsorbed and is therefore difficult to detect in urine. The constant elimination of small amounts of albumin in the urine can be the first symptom of kidney damage. In the healthy kidney, albumin is usually glomerularly filtered and tubularly reabsorbed and is therefore difficult to detect in urine. With a damaged kidney this process is affected. The elimination of albumin at a rate of 20-200 mg/L can be defined as microalbuminuria. This microalbumin test allows for the detection of such small concentrations. Especially in diabetic subjects, a positive result may indicate the onset of diabetic nephropathy. Without adequate therapeutic intervention, a high percentage of patients could develop complications. The elimination of albumin constantly increases (= microalbuminuria) and, after a few years, results in renal failure, which makes dialysis or kidney transplantation inevitable. A globally recognized study (DEMAND) shows that about 41% of type 2 diabetics have microalbuminuria. The frequency of microalbuminuria increases with age, blood pressure and the duration of diabetes, and is rarer when the blood sugar level is kept under control. The high prevalence of the disease reveals the importance of annual control of microalbuminuria for diabetics. For type 1 diabetics, the first evaluations are recommended around 5 years after the onset of the disease. For type 2 diabetics, screening should begin at the first diagnosis, since the exact onset of the disease is not known. The diagnosis of microalbuminuria is also important because it is not only the first sign of nephropathy, but also of an increased cardiovascular risk for type 2 diabetics. An increase in albumin elimination may be due to other factors such as physical activity, urinary tract infections, high blood pressure, heart failure or surgical interference (as well as damage to the kidney structure). If the increased albumin expulsion disappears after excluding one of these factors, it could only be a transient albuminuria without pathological causes. Since albumin expulsion can vary substantially from day to day, at least 2 out of 3 urine samples, collected over a period of 3-6 months, should show increased albumin values, before diagnosing microalbuminuria. The Microalbuminuria Test Cassette (Urine) identifies Microalbumin based on immunofluorescence. The sample moves over the sample swab strip on the absorbent pad. The microalbumin in the urine will compete with the microalbumin antigen that covers the membrane. The less microalbumin there is in the sample, the more likely it is that the anti-microalbumin antibodies conjugated to the fluorescent microspheres will be captured by the microalbumin antigen that covers the membrane (test line). The concentration of microalbumin in the sample is inversely proportional to the intensity of the fluorescent signal captured on the T line. According to the fluorescence intensity of the test and the standard curve, the concentration of microalbumin in the sample can be calculated by the SCREEN® Analyzer to show the concentration of microalbumin in the sample.

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